Antibiotic A80190-producing Actinomadura oligospora and process

Details Antibiotic A80190-producing Actinomadura oligospora and process Antibiotic A80190-producing Actinomadura oligospora and process

1985-10-15

1987-07-28

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435253, 435825, C12N 120, C12P 1960, C12R 103

Patent

active

046832017

ABSTRACT:
New polyether antibiotic A80190, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80190 by culture of Actinomadura oligospora NRRL 15877 and synergistic compositions of the A80190 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.

REFERENCES:
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patent: 4195079 (1980-03-01), Celmer et al.
patent: 4293650 (1981-12-01), Florent et al.
patent: 4407946 (1983-10-01), Labeda et al.
J. Tone et al., "CP-47,433 and CP-47,434, New Polycyclic Ether Antibiotics Produced by a New Species of Actinomadura," and Current Chemotherapy and Infectious Disease, J. D. Nelson and C. Grassi, Eds., vol. I, American Society for Microbiology, Washington, D.C. 1980, pp. 469-470.
Nakamura et al., "A New Species of Actinomadura Producing a Polyether Antibiotic, Cationmycin," J. Antibiotics 36, 1468-1472 (1983).
Derwent Abstract No. 83-834403/49 of European Patent 95-154-A to Fujisawa Pharm. KK.
"Polyether Antibiotics, Naturally Occurring Acid Ionophores, vol. 1, Biology", J. W. Westley, Ed., Marcel Dekker Inc., New York, 1982, pp. viii-xi.
"Polyether Antibiotics, Naturally Occuring Acid Ionophores, vol. 2, Chemistry, J. W. Westley Ed., Marcel Dekker, Inc., New York, 1983, p. 197 and excerpts from pp. 223-224.

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