Method of use of 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-ami

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514210, 514218, 5142282, 5142338, 514253, 514314, 514316, 514321, 514323, 514397, 514414, 514415, 514419, A61K 3140, A61K 31535

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active

048852953

ABSTRACT:
3-Arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, useful as analgesic, anti-rheumatic and anti-inflammatory agents, are prepared by reacting a 3-arylcarbonyl- or 3-cycloalkylcarbonylindole with an aminoalkyl halide in the presence of an acid-acceptor; by reacting a 1-aminoalkyl-1H-indole with an arylcarboxylic acid halide or a cycloalkanecarboxylic acid halide in the presence of a Lewis acid; or by reacting a 3-arylcarbonyl- or 3-cycloalkanecarbonyl-1-tosyloxyalkyl- or haloalkyl-1H-indole with an amine.

REFERENCES:
patent: 4105777 (1978-08-01), Allais et al.

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