Antiarrhythmic agents: aryl cyanoguanidine potassium channel blo

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514212, 5142278, 5142318, 5142355, 5142358, 5142378, 5142382, 5142385, 514252, 514255, 514315, 514317, 514318, 514326, 514331, 514341, 514343, 514401, 514402, 514408, 514422, 514588, 514597, 514602, 514604, 514605, 514609, 514634, 540609, 540610, 544 59, 544163, 544360, 544372, 544396, 546191, 546193, 546194, 546223, 546230, 546246, 546278, 548351, 548352, 548566, 548567, 548568, 548569, 564 48, 564 49, 564 50, 564 80, 564 84, 564 90, 564 91, 564 92, 564 99, 564105, A61K 3154, A61K 31495, A61K 31445, A61K 3

Patent

active

050065238

ABSTRACT:
Novel compounds of the formula ##STR1## and tautomers thereof are disclosed. These compounds possess potassium channel blocking activity and, as such, are useful as antiarrhythmic agents.

REFERENCES:
patent: 4057636 (1977-11-01), Petersen
patent: 4876262 (1989-10-01), Oinuma et al.
patent: 4895840 (1990-01-01), Shanklin, Jr.
Tilley et al, Chem. Abst. 93-197547h, (1980).
"Pinacidil: A New Antihypertensive Agent", Drugs Today, vol. 25, No. 1, pp. 65-74 (1989), I. Ahnfelt-Ronne et al.
"Electrophysioligic and Antiarrhythmic Activities of 4-Amino-N-[2-(diethylamino)ethyl]-3,5-dimethylbenzamide, a Sterically Hindered Procainamide Analogue", Jour. Med. Chem., 1988, vol. 3, No. 7, pp. 1290-1295, D. W. Robertson et al.
"Synthesis and Class III Antiarrhythmic Activity of (Phenylbut-2-enyl)ammonium Salts, Effect of Conformation on Activity", Jour. Med. Chem., 1986, vol. 29, No. 8, pp. 1398-1405, T. K. Morgan et al.
J. R. Harper, Jr., M.D. et al., "A Reexamination of Antiarrhythmic Drug Classification", CVR&R, Jun. 1988, pp. 59-65.
R. S. Bexton et al., "Drugs with a Class III Antiarrhythmic Action", Pharmac. Ther., vol. 17, pp. 315 to 355 (1982).
S. Donoghue et al., "Anti-arrhythmic Agents", Drugs of Today, vol. 24, No. 1, pp. 39-52, (1988).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antiarrhythmic agents: aryl cyanoguanidine potassium channel blo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiarrhythmic agents: aryl cyanoguanidine potassium channel blo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiarrhythmic agents: aryl cyanoguanidine potassium channel blo will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2034599

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.