Di- or tripeptide renin inhibitors containing lactam conformatio

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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Details

514 18, 530323, 530331, 548408, 548344, 548467, 548550, 544141, 544139, 546112, 546208, 546210, A61K 3702, C07K 502, C07F20954, C07D20712

Patent

active

050065114

ABSTRACT:
Enzyme di- or tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptides.

REFERENCES:
patent: 4384994 (1983-05-01), Veber et al.
patent: 4478826 (1984-10-01), Veber et al.

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