Heterocyclic boron compounds as intermediates for angiotensin II

Details Heterocyclic boron compounds as intermediates for angiotensin II Heterocyclic boron compounds as intermediates for angiotensin II

1992-01-17

1993-09-14

Mars, Howard T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546290, 546301, 546303, C07D215233

Patent

active

052450350

ABSTRACT:
The invention concerns novel boron compounds of the formula IV, in which Q, Y.sup.1, G.sup.1 and G.sup.2 have the various meanings defined herein, and their acid and base addition salts. The said compounds are useful in the manufacture of certain quinoline, pyridine and imidazole derivatives which have angiotensin II inhibitory activity. The invention also provides novel processes for the production of the quinoline, pyridine and imidazole derivatives. ##STR1##

REFERENCES:
H. R. Snyder et al. "Synthesis of Aromatic Boronic Acids, Aldehydo Boronic Acids and a Boronic Acid Analog of Tyrosine" J. Amer. Chem. Soc. (1958), 80, 835-838.
N. Miyaura et al. "The Palladium-Catalyzed Cross-Coupling Reaction of Phenylboronic Acid with Haloarenes in the Presence of Bases" Synth. Commun. (1981), 11, 513-519.

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