Stable aqueous solutions of prymicin and pharmaceutical and cosm

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514788, 514970, 514844, 536 65, A61K 3170

Patent

active

052448800

ABSTRACT:
The invention relates to novel stable aqueous primycin solutions containing 0.5 to 1.75% by mass/volume of primycin sulfate or 2.5 to 9% by mass/volume of a complex of primycin N-methylpyrrolidone and 2 to 15% by mass/volume of pyroglutamic acid, preferably L-pyroglutamic acid or a soluble salt, preferably the sodium salt thereof as calculated for the volume of the solution to be prepared and 40 to 60% by volume of isopropanol as calculated for the volume of the solution to be prepared as well as water in an amount adding up to 100%. The stable, aqueous primycin solutions are topical antibiotics.

REFERENCES:
patent: 3920814 (1975-11-01), Bocher et al.
patent: 4064238 (1977-12-01), Bocher et al.
patent: 4782141 (1988-11-01), Dekany et al.
patent: 4789667 (1988-12-01), Makino et al.
patent: 5064815 (1991-11-01), Szentmiklosi et al.
Szentmiklosi et al, Chemical Abstract vol. 108 (1988) No. 62454h.

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