Tricyclic compounds useful for inhibition of G-protein function

Details Tricyclic compounds useful for inhibition of G-protein function Tricyclic compounds useful for inhibition of G-protein function

1996-09-11

1997-12-30

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 93, A61K 3144, C07D47104, C07D40104, C07D22106

Patent

active

057030901

ABSTRACT:
A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a novel compound of the formula (Ia), (Ib) or (Ic) ##STR1## wherein: R and R.sup.1 are H, alkyl, halogeno, OH, alkoxy, NH.sub.2, alkylamino, dialkylamino, CF.sub.3, SO.sub.3 H, CO.sub.2 R.sup.3, NO.sub.2, SO.sub.2 NH.sub.2, or CONHR.sup.4 ;

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