Pyrrolidinylalkylcarboxylic acid amide derivatives, their prepar

Details Pyrrolidinylalkylcarboxylic acid amide derivatives, their prepar Pyrrolidinylalkylcarboxylic acid amide derivatives, their prepar

1980-06-03

1982-07-27

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032625, 26032643, 424263, 546281, A61K 3140, A61K 3144, C07D20727, C07D207273

Patent

active

043417906

ABSTRACT:
2-Oxo-1-pyrrolidinylalkylcarboxylic acid amides of formula I ##STR1## in which R represents a hydrogen atom or hydroxy group, R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents a substituted or unsubstituted pyridyl group or a substituted phenyl group, the substitution being by from 1 to 3 substituents, which may be the same or different selected from halogen atoms, trifluoromethyl, nitro and acetyl groups, straight or branched-chain alkyl groups having 1-4 carbon atoms, alkoxy groups having 1-4 carbon atoms, straight or branched-chain alkylmercapto groups having 1-7 carbon atoms, substituted alkylmercapto groups of the general formula II ##STR2## in which n represents 1 or 2, R.sub.3 is a hydrogen atom or a methyl group and R.sub.4 is a hydroxy group or an amino group of the general formula V ##STR3## in which R.sub.8 represents a hydrogen atom or methyl group and R.sub.9 represents a methyl group or substituted or unsubstituted benzyl group, or R.sub.8 and R.sub.9 together with the nitrogen atom shown in formula V, form a substituted pyrrolidine ring; sulphonyl groups of the general formula III

REFERENCES:
patent: 2778834 (1957-01-01), Bruce et al.
patent: 4118396 (1978-10-01), Pifferi et al.
patent: 4124594 (1978-11-01), Monguzzi et al.
patent: 4173569 (1979-11-01), Banfi et al.
Albertson, Organic Reactions, vol. 12, (Adams et al., ed., New York, 1962), pp. 205-213.

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