Cycloaliphatic prostaglandin analogues

Details Cycloaliphatic prostaglandin analogues Cycloaliphatic prostaglandin analogues

1978-11-20

1982-07-27

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032633, 26032645, 424267, 546221, C07D20738, A61K 3140

Patent

active

043417892

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: m is 1 or 2; n is 4 to 8; X is CO, protected CO, or CROH wherein R is hydrogen or C.sub.1-4 alkyl and wherein the OH moiety may be protected; R.sub.1 is hydrogen or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1 to 12 carbon atoms; R.sub.3 is hydroxy, or protected hydroxy; R.sub.2 and R.sub.4 are separately hydrogen, C.sub.1-9 alkyl, C.sub.5-8 cycloalkyl, C.sub.5-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl C.sub.1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or nitro groups; or R.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; and salts thereof; except that when one of R.sub.2 and R.sub.4 is hydrogen or C.sub.1-4 alkyl then the other of R.sub.2 and R.sub.4 cannot be hydrogen or C.sub.1-9 alkyl; have useful pharmacological properties including antigastric secretion, bronchodilator and platelet aggregration inhibition activities.

REFERENCES:
patent: 4003911 (1977-01-01), Scribner
patent: 4136190 (1979-01-01), Cassidy et al.
patent: 4138407 (1979-02-01), Cassidy et al.
patent: 4156730 (1979-05-01), Moore et al.
patent: 4177283 (1979-12-01), Cassidy et al.
patent: 4187312 (1980-02-01), Cassidy et al.
patent: 4262008 (1981-04-01), Cassidy et al.

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