Process for the preparation of carbapenem antibiotics

Details Process for the preparation of carbapenem antibiotics Process for the preparation of carbapenem antibiotics

1980-10-10

1982-07-27

Lee, Mary C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239A, 546272, C07D48704

Patent

active

043417060

ABSTRACT:
Disclosed is a process for the synthesis of carbapenem antibiotics I and their pharmaceutically acceptable salts and esters from 1: ##STR1## wherein: R.sup.7, R.sup.6, R.sup.1, R.sup.2 and R.sup.8 are selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, spirocycloalkyl, cycloalkylalkyl, alkylcycloalkyl, aryl, aralkyl, aralkenyl, aralkynyl, heteroalkyl, heteroaralkyl, heterocyclyl and heterocyclyalkyl.

REFERENCES:
patent: 4223038 (1980-09-01), Smale
patent: 4262009 (1981-04-01), Christensen et al.
patent: 4262010 (1981-04-01), Christensen et al.
patent: 4289696 (1981-09-01), Smale

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