Enkaphalin derivatives

Details Enkaphalin derivatives Enkaphalin derivatives

1980-03-14

1982-07-27

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

043416985

ABSTRACT:
Novel analgesic and antipsychotic agents having the formula ##STR1## wherein Q is ##STR2## in which R.sub.1 is hydrogen, hydroxy or halogen and R.sub.4 is hydrogen or, R.sub.1 and R.sub.4 are both hydroxy; Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms and X is methylene, carbonyl, hydroxymethylene, thio, sulfinyl or sulfonyl, or Z and X, taken together, are methylidenyl, with the proviso that when X is sulfonyl or sulfinyl, Z is other than hydrogen; R.sub.5 is hydrogen or halogen, and R.sub.2 is H, a straight or branched lower alkyl group having from 1 to 4 carbon atoms, the group ##STR3## or the group ##STR4## wherein R.sub.3 is hydroxy, amino, alkylamino or dialkylamino wherein the alkyl moiety is straight or branched and has from 1 to 4 carbon atoms, diastereomers, enantiomers and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4254107 (1981-03-01), Veber et al.
Di Maio, et al., Chem. Abstr. 91, (1979), 151082h.
Di Maio, et al., Chem. Abstr. 94, (1981), 185903d.
J. Di Maio, P. W. Schiller & B. Belleau, Peptides Structure and Biological Function, E. Gross & J. Meienhofer, Eds. (Pierce Chemical Co., Rockford, Ill.), pp. 889-892, (Dated Dec. 1979; published about Mar. 1980).

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