Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142282, 5142285, 5142352, 5142355, 5142358, 514253, 514320, 544120, 544121, 544122, 544124, 544129, 544141, 544151, 544376, 544 61, 544 90, 544 91, 544 92, A61K 31535, A61K 3154, C07D41304, C07D41314

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active

057030758

ABSTRACT:
This invention relates to compounds of Formula I ##STR1## which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of Formula I are useful inhibitors of cell proliferation.

REFERENCES:
patent: 3491092 (1970-01-01), Grigat et al.
patent: 4092416 (1978-05-01), Winter et al.
Lee, K.T. "Atherosclerosis" Annals of N.Y. Academy of Science, v. 454, p. 42 (1985) * copy in parent case.
Derwent Abstract, Accession No. 79169A/44 (Japanese JA-025657) (1979).
Derwent Abstract, Accession No. 87-150605/21 (Japanese JP-259603) (1987).
Eaton, R. P., "High Density Lipoprotein--Key to Anti-Atherogenesis", J. Chron. Dis. 31:131-135 (1978).
Haust, M. D., "Reaction Patterns of Intimal Mesenchyme to Injury and Repair in Atherosclerosis", Adv. Exp. Med. Biol. 43:35-57 (1974).
Schurr, P. E., et al., "High Volume Screening Procedure for Hypobetalipoproteinemic Activity in Rats", Adv. Exp. Med. Biol. 67:215-229, Plasma Press (1975).
Day, C. E., et al., "Utility of a Selected Line (SEA) of the Japanese Quail (Coturnix Coturnix Japonica) for the Discovery of New Anti-Atherosclerosis Drugs", Lab. An. Sci. 27(5):817-821 (1977).
Mazzel, M., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco, Ed. Sci. 40:895-908 (1985).
Mazzei, M., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco. Ed. Sci. 41:611-621 (1986).
Balbi, A., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco. Ed. Sci. 37:582-596 (1982).
Ermili, A., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco. Ed. Sci. 32:375-387 (1977).
Ermili, A., et al., "Ricerche Chimiche E Farmacologiche Su Derivati Piranici", Farmaco. Ed. Sci. 32:713-724 (1977).
Balbi, A., et al., "Nitroderivati Di 2-(Dialchilammino)Cromoni", Farmaco. Ed. Sci. 38:784-793 (1983).
Balbi, A., et al., "Nitroderivati Di 2-(Dialchilammino)Cromoni", Farmaco. Ed. Sci. 41(7):548-547 (1986).
Mouysset, G., et al., "Pharmacomodulation d'adreenolytiques .alpha. en serie benzopyrqnnique", Eur. J. Med. Chem. 22(6):539-544 (1987).
Eiden, F., et al., "Uber die Reaktion von 3-Hydroxychromon mit Aminen", Arch. Pharm. (Weinheim Ger.) 308:385-388 (1975).
Ali, S. A., et al., "The Chemistry of Fungi. Part LXVII. Synthesis of J. Chem. Soc. Perkin Trans. I:173-174 (1973).
Eiden, F. and G. Rademacher, "Synthese und Reaktionen von 3-Acyl-2-methylthio-chromonen", Arch. Pharm. (Weinheim Ger.) 316:34-42 (1983).
Bantick, J. R. and J. L. Suschitzky, "Synthesis of 2-Aminochromones. Studies on the Nucleophilic Displacement of Sulphinyl and Sulphonyl Groups in the 2-Position of 5,8-Dimethoxychromone", J. Heterocyclic Chem. 18:679-684 (1981).
Mazzei, M., et al., "Synthesis and Anti-Platelet Activity of Some 2-(Dialkylamino)Chromones", Eur. J. Med. Chem. 23:237-242 (1988).
Tronchet, J. M. J., et al., "Enaminosucres et sucres halogenoacetyleniques", Helv. Chim. Acta 59:941-944 (1976).
Grigat, E., et qal., "4H-1.3-Benzoxazinon-Derivate aus aromatischen Cyansaureestern mit einer ortho-standigen carbonsaurefunktion", Chem. Ber. 97:3036-3044 (1964).
Jpn. Tokkyo Koho 79 20,504, "Oxazine and Thiazine Derivatives", CA 91:157755b, p. 644, (1979).
Jpn. Kokai 72 17,781, "Oxazine or Thiazine Derivatives", CA 77:140107e, p. 454 (1972).
Kokel, B., et al., "A New `One Pot` Preparation of Corresponding Ortho Hydroxynitriles and Phosgeniminium Salts", Tet, Letters, 25(35):3837-3840 (1984).
Palazzo, S. and L. I. Giannola, "Reazione Della 2H-1,3-Benzossazina-2-Tione-4(3H)-One Con Ammine Primarie", Atti. Acad. Sci. Lett., Parte 1. 34(2):83-87 (1976).
Brunetti, H. and C. E. Lothi, "Die Synthese von Asymmetrisch Substituierten o-Hydroxyphenyl-s-triazinen", Helv. Chim. Acta, 55:1566-1595 (1972).

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