Process for preparing osteogenesis promoting substance

Details Process for preparing osteogenesis promoting substance Process for preparing osteogenesis promoting substance

1993-01-22

1993-09-14

Sever, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210645, 210651, 210652, B01D 6114, B01D 6122

Patent

active

052445771

ABSTRACT:
A process for preparing an osteogenesis promoting substance, which comprises extracting a demineralized bone powder with a solution of chaotorpic reagent, subjecting the extracted solution to ultrafiltration to collect a fraction containing substances ranging from 1,000 to 100,000 daltons as molecular weight, dialyzing the collected fraction and collecting the water-insoluble fraction from the dialyzing liquid. The osteogenesis promoting substance prepared by the present invention is useful as a bone repairing agent and a bone grafting agent.

REFERENCES:
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4455256 (1984-06-01), Urist
patent: 4743259 (1988-05-01), Bolander et al.
patent: 5011691 (1991-04-01), Oppermann et al.
Journal of Biomedical Materials, 24:639 (1990).
M. Urist et al., Methods in Enzymology, 146:294 (1987).

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