Production of tumor angiogenesis factor by cell culture

Details Production of tumor angiogenesis factor by cell culture Production of tumor angiogenesis factor by cell culture

1978-12-29

1980-10-21

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

435 68, 435241, 435811, 435948, 424 95, C12P 100

Patent

active

042295327

ABSTRACT:
Process for the production of human TAF in vitro comprising growing the human osteosarcoma cell line MG-63 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.

REFERENCES:
patent: 4059485 (1977-11-01), Tolbert
patent: 4059486 (1977-11-01), Tolbert
Billiau et al., Antimicrob. Agents Chemothr. 12, (1), 11-15 (1977).
Folkman et al., Fundamental Aspects of Neoplasia, pp. 401-412, Springer-Verlag, N.Y., (1975).
Folkman et al., J. Exptl. Med. 133, 275-288 (1971).
Phillips et al., Int. J. Cancer 17, 549-558 (1976). _
Hubler et al., Cancer 38, 187-192 (1976).

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