PLA.sub.2 inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

562 13, 562 21, C07F 940, C07F 938

Patent

active

055042376

ABSTRACT:
PIA.sub.2 inhibitors selected from the group consisting of ##STR1## wherein A is selected from the group consisting of ##STR2## and Z, W, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, X, X' and Y are as defined herein.

REFERENCES:
patent: 4818774 (1989-04-01), Kem
patent: 5043330 (1991-08-01), Nguyen et al.
patent: 5112864 (1992-05-01), Djuric et al.
patent: 5135941 (1992-08-01), Djuric et al.
patent: 5204336 (1993-04-01), Kruse et al.
Zupan, L. A. et al., "Calcium is Sufficient But Not Necessary for Activation of Sheep Platelet Cytostolic Phospholipase A.sub.2 ", FEBS Letters, vol. 284, No. 1, 27-30 (1991).
Buckle, D. R., "Synthesis of Aryloxy Analogues of Arachidonic Acid via Wittig and Palladium-catalysed Cross-coupling Reactions", J. Chem. Research (S), 1987, pp. 394-395.
Foster, K. A., "Arachidonic Acid Analogues as Inhibitors of of Phospholipase A.sub.2 Activity", vol. 15, pp. 418-419 (1987).
Reid, I. R. et al., "Two-Year Follow-up of Biphosphonate (APD) Treatment in Steroid Osteoporosis", The Lancet, 1988, p. 1144.
Creary, X. et al., J. Am. Chem. Soc. 1983, 105 (9), 2851-8.
Yuan, C. et al., Phosphorus, Sulfur Silicon Relat. Elem. 1992, 69 (1-2), 75-81' Chem. Abstr. 117(17): 171559c.
Moskovin, A. V. et al., Zh. Obshch. Khim 1984, 54(10). 2223-37' Chem. Abstr. 102(17)" 149357d.
Robinson, C. N. et al., J. Org. Chem. 1987. 52(10). 2011-15' QD241/06.
Lehnert, W. Tetrahedron 1974. 30(2). 301-5; QD241.T4.
Kosolapoff, G. M. Organophospherus Compounds; John Wiley and Sons: New York, 1950; pp. 113-120; QD412.P1K5.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

PLA.sub.2 inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with PLA.sub.2 inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PLA.sub.2 inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2017477

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.