Process for the preparation of an L-alanine compound

Details Process for the preparation of an L-alanine compound Process for the preparation of an L-alanine compound

1993-03-11

1993-12-07

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27740

Patent

active

052684830

ABSTRACT:
An improved process for the preparation of [1S-(1R*,2S*,3R*)]-N (4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4 thiazolyl)-N-[(1-cyclohexylmethyl) -2,3-dihydroxy-5-methylhexyl]-L-alaninamide is described where the key intermediate, 3-(2-amino 4-thiazolyl)-L-alanine is converted without protecting the aminothiazole group to the desired compound, as well as valuable intermediates used in the process.

REFERENCES:
patent: 2556907 (1951-06-01), Emmick
patent: 2657230 (1953-10-01), Rogers
Elrel "Stereochemistry of Chemistry Compounds" pp. 49-55 (1962).
Fogassy et al. "Tetrahedron Letters" vol. 21 (1980) pp. 647-650.

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