Substituted 10bH-oxazolo[3,2-c] [1,3] benzoxazine-2(3H), 5-dione

Details Substituted 10bH-oxazolo[3,2-c] [1,3] benzoxazine-2(3H), 5-dione Substituted 10bH-oxazolo[3,2-c] [1,3] benzoxazine-2(3H), 5-dione

1992-07-06

1993-12-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D26308

Patent

active

052684768

ABSTRACT:
A novel process for the preparation of .alpha.-alkylated .alpha.-amino acids and .alpha.-halogenated .alpha.-amino acids is disclosed. These .alpha.-alkylated .alpha.-amino acids and .alpha.-halogenated .alpha.-amino acids are useful as intermediates for the preparation of enzyme inhibitors (for example, renin inhibitors) and other peptides or amino acid derivatives or analogs.

REFERENCES:
patent: 4264771 (1981-04-01), Steglich et al.
patent: 4371706 (1983-02-01), Edmonds et al.
patent: 4508921 (1985-04-01), Amato et al.
patent: 5164388 (1992-11-01), De
Zydowsky et al. Jour. Org. Chem. vol. 55 pp. 5437-5439 (1990).
Zydowsky, et al., Abstract No. ORGN 240, 199th Amer. Chem. Soc. Nat. Mtg. Apr. 22-27, 1990.
Block, et al. J. Chem. Soc. (C) 329 (1971).
Schollkopf, Angew, Chem. Int. Ed. Engl. 2 117 (1978).
Schollkopf, Synthesis 271 (1984).
Schollkopf, Liebigs Ann. Chem. 399 (1987).
Seebach, Helv. Chim. Acta 68 1243 (1985).
Belokon, J. Chem. Soc., Chem. Commun 171 (1985).
Ihara, J. Org. Chem. 54 5413 (1989).
Ojima, Tetrahedron 5307 (1988).
Fitzi, Tetrahedron 44 5277 (1988).
Kruizinga, J. Org. Chem. 53 1826 (1988).
Fadel, Tet. Lett. 28 2243 (1987).

Affiliated with

Also associated with

Rating

Substituted 10bH-oxazolo[3,2-c] [1,3] benzoxazine-2(3H), 5-dione does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted 10bH-oxazolo[3,2-c] [1,3] benzoxazine-2(3H), 5-dione, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted 10bH-oxazolo[3,2-c] [1,3] benzoxazine-2(3H), 5-dione will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2016803