Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-05-26
1996-04-02
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514821, 514935, A61K 3116
Patent
active
055041167
ABSTRACT:
The use of lidocaine or other Class I cardiac antiarrhythmic compound in the management of preterm labor and the stoppage of labor preparatory to cesarian delivery, is disclosed. The electrophysiological effects of lidocaine on the sodium, calcium and potassium channels of freshly dissociated myocytes from late-pregnant rat uteri with the tight-seal patch-clamp method are presented. Dose-response relations on the sodium and calcium currents, and effects on the availability relation for sodium current are also presented. Also disclosed are the effects of chronic administration of lidocaine on the duration of pregnancy.
REFERENCES:
patent: 5091387 (1992-02-01), Evans et al.
patent: 5095003 (1992-03-01), Goetz et al.
patent: 5175159 (1992-12-01), Bock et al.
patent: 5198463 (1993-03-01), Pettibone et al.
patent: 5204349 (1993-04-01), Bock et al.
patent: 5225528 (1993-06-01), Bock et al.
patent: 5242947 (1993-07-01), Cherskey et al.
Inoue Y., Sperelakis N. Gestational change in Na.sup.+ and Ca.sup.2+ channel current densities in rat myometrial smooth muscle cells. Am. J. Physiol. 1991; 260:C658-C663.
Miyoshi H., Urabe T. Fujiwara A. Electrophysiological properties of membrane currents in single myometrial cells isolated from pregnant rats. Eur J. Physiol. 1991; 419:386-393.
Inoue, Y., Nakao K., Okabe, K., Izumi H., Kanda S., Kitamura K., Kuriyama H. Some electrical properties of human pregnant myometrium. Am. J. Obstet. Gynecol. 1990; 162:1090-1098.
Yoshino M., Wang S. Y., Kao C. Y. Ionic currents in smooth myocytes of the pregnant rat uterus. J. Gen. Physiol. 1989; 94:38a (abstract).
Ohya Y., Sperelakis N. Fast Na.sup.+ and slow Ca.sup.2+ channels in single uterine muscle cells from pregnant rats. Am. J. Physiol. 1989; 257:C408-C412.
Young R. C., Herndon-Smith L. Characterization of sodium channels in cultured human uterine smooth muscle cells. Am. J. Obstet. Gynecol. 1991; 164:175-181.
Nakai Y., Kao C. Y. Changing properties of Na.sup.+ and Ca.sup.2+ components of the early inward current in rat myometrium during pregnancy. Fed. Proc. 1983; 42:313 (abstract).
Kao C. Y., McCullough, J. R. Ionic currents in the uterine smooth muscle. J. Physiology (London) 1975; 246:1-36.
Kao C. Y. Wakui, M., Wang, S. Y., Yoshino, M. The outward current of the isolated rat myometrium., J. Physiol. 1989; 418:20P.
Chemical Abstracts 113:52387, 1989, Li et al.
Chemical Abstracts 90:162013, 1979, Willdeck-Lund et al.
Chemical Abstracts 90:197480, 1978, Lampa et al.
"Facts and Comparisons", Olin et al. (Editors), J. B. Lippincott Co., St. Louis, MO, 1990, pp. 145-145a.
Kao Chien-yuan
Wang Shuya
Cintins Marianne M.
Moezie M.
Research Foundation of State University of New York
LandOfFree
Lidocaine for the management of preterm labor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lidocaine for the management of preterm labor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lidocaine for the management of preterm labor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2016683