Tricyclic pyrone derivatives as protease inhibitors and antivira

Details Tricyclic pyrone derivatives as protease inhibitors and antivira Tricyclic pyrone derivatives as protease inhibitors and antivira

1993-11-19

1996-04-02

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514885, 549280, A61K 3135, C07D31178

Patent

active

055041043

ABSTRACT:
The present invention relates to novel substituted tricyclic pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The tricyclic pyrone derivatives are useful in the development of therapies for the treatment of vital infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized tricyclic pyrones and of related structures.

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