Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-11-18
1993-12-07
Siegel, Alan
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514357, 514415, 514427, 514399, 514471, 514521, 514523, 514385, 514443, 514418, 514419, 514520, 514522, 514524, 514525, 514517, 514518, 514519, 514603, 514619, 514649, 514657, 514 95, 514 96, A61K 3138, A61K 3134, A61K 3142, A61K 3145
Patent
active
052683850
ABSTRACT:
This invention provides a method for treating the symptoms of schizophrenia by interacting selectively with presynaptic dopaminergic D.sub.2 receptors without appreciably activating postsynaptic dopamine receptors which comprises administering to a schizophrenic an effective amount of a compound selected from the group consisting essentially of the stereoisomers of mixtures thereof of compounds represented by the general formula: ##STR1## wherein R.sub.1 is selected from the group consisting of pyridyl and ##STR2## X is oxygen or sulfur, Y, if present, is selected from the group consisting of hydroxy, nitro, cyano, azido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12 carbon atoms, and a is an integer between zero and 3, R.sub.2 is H, R.sub.4 is OA and R.sub.3 is selected from the group consisting of H and OA, A is H or is selected from the group consisting of hydrocarbyl radicals, or ##STR3## R.sub.5 is selected from the group consisting of hydrocarbyl radical and n is 2 or 3.
REFERENCES:
patent: 4465692 (1984-08-01), Horn
patent: 4564628 (1986-01-01), Horn
patent: 4657925 (1987-04-01), Horn
patent: 4722933 (1988-02-01), Horn
patent: 4743618 (1988-05-01), Horn
patent: 4882352 (1989-11-01), Horn
Hammond Richard J.
Siegel Alan
Whitby Research, Inc.
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