Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-03-31
1996-11-05
Zitomer, Stephanie W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2433, 435 6, 435 912, 935 77, 935 78, C07H 2104, C12P 1934, C12Q 168
Patent
active
055719058
ABSTRACT:
A new human gene termed MCC is disclosed. Methods, primers, probes and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. These results suggest that MCC is a tumor suppressor.
REFERENCES:
patent: 5352775 (1994-10-01), Albertsen et al.
patent: 5420263 (1995-05-01), Burrell et al.
Ashton-Rickardt, et al., "High Frequency of APC Loss in Sporadic Colorectal Carcinoma Due to Breaks Clustered in 5q21-22", Oncogene, 4:1169-1174, (1989).
Bodmer, et al., "Localization of the Gene for Familial Adenomatous Polyposis on Chromosome 5", Nature, 328:614-619, (1987).
Delattre, et al., "Multiple Genetic Alterations in Distal and Proximal Colorectal Cancer," The Lancet, vol. II, No. 8659, pp. 353-356 (Aug. 12, 1989).
Fearon, et al., "Identification of a Chromosome 18q Gene That Is Altered in Colorectal Cancers," Science, 247:49-56 (1990).
Fearon, et al., "A Genetic Model for Colorectal Tumorigenesis," Cell, 61:759-767 (1990).
Herrera, et al., "Brief Clinical Report: Gardner Syndrome in a Man With an Interstitial Deletion of 5q," Am. J. of Med. Genet., 25:473-476 (1986).
Monaco, et al., "Isolation of Candidate cDNAs for Portions of the Duchenne Muscular Dystrophy Gene," Nature, 323:646-650 (1986).
Nakamura, et al., "Localization of the Genetic Defect in Familial Adenomatous Polyposis Within a Small Region of Chromosome 5," Am. J. Hum. Genet., 43:638-644 (1988).
Okayama, et al., "Rapid Nonradioactive Detection of Mutations in the Human Genome by Allele-Specific Amplification," J. Lab Clin. Med., 114:105-113 (1989).
Rommens, et al., "Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping," Science, 245:1059-1065 (1989).
Ruano, et al., "Direct Haplotyping of Chromosomal Segments from Multiple Heterozygotes Via Allele-Specific PCR Amplification," Nucleic Acids Res., 17:8392 (1989).
Sasaki, et al., "Loss of Constitutional Heterozygosity in Colorectal Tumors from Patients with Familial Polyposis Coli and Those with Nonpolyposis Colorectal Carcinoma," Cancer Research, 49:4402-4406, 1989.
Viskochil, et al., "Deletions and a Translocation Interrupt a Cloned Gene at the Neurofibromatosis Type 1 Locus," Cell, 62:187-192 (1990).
Vogelstein, et al., "Genetic Alterations During Colorectal-Tumor Development," New Eng. J. Med., 319:525-532 (1988).
Wallace, et al., "Type 1 Neurofibromatosis Gene: Identification of a Large TRanscript Disrupted in Three NF1 Patients," Science, 249:181-186 (1990).
Wu, et al., "The Ligation Amplification Reaction (LAR)--Amplification of Specific DNA Sequences Using Sequential Rounds of Template-Dependent Ligation," Genomics, 4:560-569, 1989.
International Search Report of Co-pending PCT Application PCT/US92/00377.
Tanaka, et al., "Suppression of Tumorigenicity in Human Colon Carcinoma Cells by Introduction of Normal Chromosome 5 or 18", Nature, 349:340-342 (1991).
Kinzler, et al., "Identification of Gene Located at Chromosome 5q21 that is Mutated in Colorectal Cancers", Science, 251:1366-1370 (1991).
Marx, "Gene Identified for Inherited Cancer Susceptibility," Science, 253:616 (1991).
Baker et al., "Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas", Science, 244:217-221 (1989).
Kinzler Kenneth W.
Nakamura Yusuke
Vogelstein Bert
White Raymond
The Cancer Institute
The Johns Hopkins University
University of Utah
Zitomer Stephanie W.
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