Dihydropyrimidine derivatives

Details Dihydropyrimidine derivatives Dihydropyrimidine derivatives

1994-01-11

1995-11-28

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544295, 544243, 544244, 544310, 544311, 544312, 544313, 544314, 544319, 544321, 544330, 544331, 544332, 544333, 544335, 544 586, 544 60, 544 61, 544 82, 544116, 544117, 544122, 544123, 544278, 544279, 544280, 544283, 544249, 544284, 544285, 544286, 544287, 544289, 544290, 544292, 540600, 540601, 540521, C07D23920, C07D23922, C07D23972, C07D23978, C07D23980, C07D23984, C07D23988, C07D23993

Patent

active

054709750

ABSTRACT:
Novel A-II receptor antagonists have the formula ##STR1## and its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as defined herein.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 5100897 (1992-03-01), Allen et al.
patent: 5268375 (1993-12-01), Bernhart et al.
patent: 5330987 (1994-07-01), Allen et al.
D. J. Carini et al., "Nonpeptide Angiotensin II Receptor Antagonists: N-[(Benzyloxy)benzyl]imidazoles and Related Compounds as Potent Antihypertensives", J. Med. Chem, 1990, 33, pp. 1330-1336.
Atwal et al., Jour. of Med. Chem. vol. 35, pp. 4751-4763 (1992).

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