Process for the preparation of intermediates useful for the synt

Details Process for the preparation of intermediates useful for the synt Process for the preparation of intermediates useful for the synt

1995-03-14

1996-11-05

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435135, 435280, 435197, 435198, C12P 1702, C12N 918, C12N 920

Patent

active

055717047

ABSTRACT:
A process for the preparation of the compounds of formula ##STR1## (wherein R has the meanings reported in the specification) by enzymatic transesterification of enantiomeric mixtures is described.
These compounds are intermediates useful in the synthesis of Diltiazem.

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Vogel "Practical Organic Chemistry"(1957) pp. 122-136.
Cambou, Bernard, et al, Biotechnology and Bioengineering, vol. 26, No. 12, Dec. 1984, pp. 1449-1454, "Comparison of Different Strategies for the Lipase-Catalyzed Preparative Resolution of Racemic Acids and Alcohols: Asymmetric Hydrolysis Esterification, and Transesterification".

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