Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1994-03-15
1995-11-28
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514729, A61K 31215, A61K 31045
Patent
active
054708770
ABSTRACT:
A method of causing carcinoma regression is disclosed. One administers an effective amount of perillic acid methyl ester. The use of perillic acid methyl ester is disclosed. A pharmaceutical composition involving perillic acid methyl ester is disclosed.
REFERENCES:
patent: 5110832 (1992-05-01), Chastain et al.
patent: 5244916 (1993-09-01), Bokoch
Crowell et al., J of Biol. Chem., vol. 266, No. 26, Sep. 15, 1991, pp. 17679-17685.
Ren, et al., "Inhibition of Ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol," Cancer Letters 76:185-190, 1994.
Gould, M., "Proposal: Phase I Evaluation of Perillyl Alcohol (NSC 641066) in Patients With Cancer," distributed in Aug., 1993.
Gould, M., "Perillyl Alcohol (NSC 641066) Summary of Activities in the Development Therapeutics Program, DCT, NCI," distributed in Feb., 1994.
Gould, et al., "Perillyl Alcohol (NSC641066) and Limonene (NSC 844) Summary for the Decision Network," distributed in Feb., 1994.
Abstract 3264, Gould, et al., "Differentiation of neuro-2a cells induced by the monoterpene, perillyl alcohol (POH)," Proceedings, Eighty-Fourth Annual Meeting, American Association for Cancer Research May 19-22, vol. 34, Mar., 1993.
Abstract 3265, Ren, et al., "Inhibition of ubiquinone biosynthesis by the monoterpene perillyl alcohol (POH)," Proceedings, Eighty-Fourth Annual Meeting, American Association for Cancer Research May 19-22, vol. 34, Mar. 1993.
Abstract 3266, Jirtle, et al., "Increased levels of TGF-.beta.1 and mannose-6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor in limonene-induced mammary tumor regression," Proceedings, Eighty-Fourth Annual Meeting, American Association for Cancer Research May 19-22, vol. 34, Mar., 1993.
Plenary Session 4: Mechanisms of action of chemopreventive agents: Basic science and clinical applications, Gould, "Chemoprevention of mammary cancer by monoterpenes," Proceedings, Eighty-Fourth Annual Meeting, American Association for Cancer Research May 19-22, vol. 34, Mar., 1993.
Abstract 3134, Crowell, et al., "Human metabolism of orally administered d-limonene," Proceedings, Eighty-Third Annual Meeting of the American Association for Cancer Research May 20-23, vol. 33, Mar., 1992.
Abstract 3135, Haag, et al., "Enhanced inhibition of protein isoprenylation and tumor growth by perillyl alcohol, an hydroxylated analog of d-limonene," Proceedings, Eighty-Third Annual Meeting of the American Association for Cancer Research May 20-23, vol. 33, Mar., 1992.
Gould, M., "Cellular and molecular aspects of the multistage progression of mammary carcinogenesis in humans and rats," Cancer Biology 4:161-169, 1993.
Crowell, et al., "Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growth," Cancer Chemother. Pharmacol. 31:205-212, 1992.
Crowell, et al., "Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene," Carcinogenesis 13(7):1261-1264, 1992.
Haag, et al., "Limonene-induced Regression of Mammary Carcinomas," Cancer Research 52:4021-4026, 1992.
Crowell, et al., "Structure-Activity Relationships Among Monoterpene Inhibitors of Protein Isoprenylation and Cell Proliferation," Biochemical Pharmacology, 47:14-15, 1994.
Elegbede, et al., "Inhibition of DMBA-induced Mammary Cnacer By The Monoterpene D-Limonene," Carcinogenesis, 5[5]:661-664, (1984).
Elegbede, et al., "Regression Of Rat Primary Mammary Tumors Following Dietary D-Limonene," JNCI, 76[2]:323-325 (1986).
Haag, et al., "Limonene-induced Complete Regression Of Rat Mammary Carcinomas," Proc. Of The Amer. Assoc. For Cancer Research, 32:402 (Apr. 11, 1991).
Elson, et al., "Anti-carcinogenic Activity Of D-Limonene During The Initiation And Promotion/Progression Stages of DMBA-Induced Rat Mammary Carcinogenesis," Carcinogenesis, 9[2]331:332, (1988).
Maltzman, et al., "Ther Prevention Of Nitrosomethylurea-Induced Mammary Tumors D-Limonene And Orange Oil," Carcinogenesis, 10[4]:781-783 (1.
Wattenberg, et al., "Inhibition Of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone Carcinogenesis In Mice By D-Limonene And Citrus Fruit Oils," Carcinogenesis, 12[1]:115-117 (1991).
Van Duuren, et al., "Cocarcinogenic And Tumor-Promoting Agents In Tobacco Carcinogenesis," Journ. of the Natl. Cancer Institute, 56[6]:1237-1242 (1976).
Homburger, et al., "Inhibition Of Murine Subcutaneous And Intraveneous Benzo(rst)pentaphene Carcinogenesis By Sweet Orange Oils and D-Limonene," Oncology, 25:1-10 (1971).
Stampfer, "Isolation And Growth Of Human Mammary Epithelial Cells," Journ. of Tissue Culture Methods, 9[2]:107-115 (1985).
Hammond, et al., "Serum-Free Growth Of Human Mammary Epithelial Cells: Rapid Clonal Growth In Defined Medium And Extended Serial Passage With Pituitary Extract," Proc. Natl. Acad Sci. USA, 81:5435-5439 (1984).
Stampfer, et al., "Induction Of Transformation And Continuous Cell Lines From Normal Human Mammary Epithelial Cells After Exposure To Benzo[a]pyrene," Proc. Natl. Acad. Sci. USA, 82:2394-2398 (1985).
Eldridge, et al., "Association Of Decreased Intercellular Communication With The Immoral But Not The Tumorigenic Phenotype In Human Mammary Epithelial Cells," Cancer Research, 49:4326-4331, (1989).
Schmidt, et al., "Evidence For Post-Translational Incorporation Of A Product Of Mavalonic Acid Into Swiss 3T3 Cell Proteins," Journ. of Biol. Chem., 259[16]:10175-10180 (1984).
Laemmli, U.K., "Cleavage Of Structural Proteins During The Assembly Of The Head Of Bacteriophage T4," Nature, 227:660-685 (1970).
Laskey, et al., "Protein Measurement With The Folin Phenol Reagent," J. Biol. Chem., 193:265-275 (1951).
Crowell, et al., "Selective Inhibition Of Isoprenylation Of 21-26kDa Protein By The Anticarcinogen d-Limonene And Its Metabolites," The Journ. of Biol. Chem., 266[26]:176-9-17685, (Sep., 1991).
Gould, "Chemoprevention And Treatment Of Experimental Mammary Cancers By Limonene," Proc. of the Amer. Assoc. For Cancer Res., 32:474-475 (Apr. 11, 1991).
Gibbs, J. B., "Ras C-Terminal Processing Enzymes-New Drug Targets," Cell, 65:1-4 (1991).
Haag, et al., "Enhanced inhibition of protein isoprenylation and tumor growth by perillyl alcohol, an hydroxylated analog of d-limonene," Proc. Annu. Meet. Am. Assoc. Cancer Res. 33:524, 1992.
Crowell, et al., "Human metabolism of oral administered d-limonene," Proc. Annu. Meet. Am. Assoc. Cancer Res. 33:524, 1992.
Seiyaku, "Novel Antiallergic Agent," Patent abstracts of Japan, 5 (8):C-39 [680], 1981.
Bronfen, et al., "Inhibition of human pancreatic carcinoma cell proliferation by perillyl alcohol," Proc. Annu. Meet. Am. Assoc. Cancer Res. 35:431, 1994.
Crowell Pamela L.
Elson Charles E.
Gould Michael N.
Ren Zhibin
Goldberg Jerome D.
Wisconsin Alumni Research Foundation
LandOfFree
Uses of perillic acid methyl ester does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Uses of perillic acid methyl ester, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Uses of perillic acid methyl ester will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2013959