Phospholipase A.sub.2 inhibitor

Details Phospholipase A.sub.2 inhibitor Phospholipase A.sub.2 inhibitor

1990-06-27

1992-03-24

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549314, 549318, 560180, 560181, 560182, 562579, 562590, 562594, 562595, 435118, 435126, 435131, 435135, 435144, 435145, C07D30794, C07C 5500, C07C 6966

Patent

active

050990349

ABSTRACT:
A compound of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are --COOR.sup.4, --COOR.sup.5, and --COOR.sup.6, respectively; R.sup.4, R.sup.5, and R.sup.6 each is hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z each is hydrogen or hydroxyl; a dotted line indicates the presence or absence of a single bond; or where W/R.sup.3, X/R.sup.1, and/or Z/R.sup.3 may be combined together, a lactone is formed, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound (I) and a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same are also provided.

REFERENCES:
patent: 4145437 (1979-03-01), Aldridge et al.

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