Process for preparing aromatic alkanols

Details Process for preparing aromatic alkanols Process for preparing aromatic alkanols

1990-01-24

1991-03-19

McFarlane, Anthony

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568715, C07C 3318

Patent

active

050012835

ABSTRACT:
Aromatic alkanols are provided by reacting an aromatic compound with a 1,2-alkylene oxide in the presence of a synthetic porous crystalline material possessing a Constraint Index of not greater than about 3. Thus, for example, isobutylbenzene is reacted with propylene oxide in the presence of zeolite Beta, ZSM-12 or MCM-22 to provide 2-(4-isobutylphenyl)propanol which can thereafter be oxidized to the corresponding carboxylic acid, the widely utilized anti-inflammatory agent ibuprofen (i.e., 2-(4-isobutylphenyl)-propionic acid).

REFERENCES:
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patent: 4439409 (1984-03-01), Puppe et al.
patent: 4443643 (1984-04-01), Watson et al.
patent: 4507512 (1985-03-01), Okumura et al.
patent: 4820882 (1989-04-01), Eckhardt et al.
patent: 4826667 (1989-05-01), Zones et al.
patent: 4849401 (1989-07-01), Friedrich et al.
patent: 4943667 (1990-07-01), Hoelderich et al.

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