Aralkyl-4H-1,2,4-triazole derivatives

Details Aralkyl-4H-1,2,4-triazole derivatives Aralkyl-4H-1,2,4-triazole derivatives

1991-06-20

1992-03-24

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5482668, A01N 43653, C07D24908

Patent

active

050989227

ABSTRACT:
The invention relates to aralkyl-4H-1,2,4-triazole derivatives, especially 5-phenyl-lower alkyl-4H-1,2,4-triazole-3-carboxamides of the formula ##STR1## in which Ph represents phenyl substituted by lower alkyl, halogen and/or by trifluoromethyl, alk represents lower alkylidene, R.sub.1 is hydrogen or lower alkyl, and R.sub.2 represents carbamoyl that is unsubstituted or is substituted by lower alkyl or by lower alkanoyl, and their salts and, as the case may be, their tautomers and the salts thereof. These compounds can be used as pharmaceutical active ingredients.

REFERENCES:
patent: 4789680 (1988-12-01), Meier
Pesson, M. "1,2,4-Triazole-5-Carboxylic Amides" CA 70:87820j (1969).
Pesson, M. et al., "1,2,4-Triazole V. N,N-Dialkylamides Derived From 1,2,4-Triazoles-Carboxylic Acids" CA 73:66517n (1970).
Ikizler, A. "Preparation of Some 1,2,4-Trizole Derivatives" CA 99:105183; (1983).
Legraverend, M. "Synthesis of S-Triazolo [4,3rd]-and-[1,5rd]-1,2,4-Triazines" CA 96:217801d (1982).

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