Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-03-07
1992-03-24
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
424537, 424538, A61K 31445, A61K 3558
Patent
active
050989146
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
This invention relates to a method and composition for treating animals, including human beings, with internal and external parasite infestation.
There are numerous flea, tick, and mite control products which involve external or topical treatment procedures including sprays, powders, dips and collars. Most of the existing products or procedures have proven largely ineffective with cats because of the cat's tendency to lick the product from its coat. Further, such topical products, which include pyrethrins and organophosphate insecticides under the brand names of Carbaryl, Malathion, Diazinon, and Dursban, have become increasingly less effective because the parasites have developed greater resistance to these products.
The applicant is aware of two products currently utilized for systemic treatment of ticks and fleas in dogs. These products are organophosphate insecticides under the brand names of Pro-Spot (13.8% fenthion), and Proban (cythioate) marketed by Haver, Mobay Corporation, Animal Health Division, Shawnee, Kans. 66201. Neither of these products are recommended for cats because of their toxicity. Organophosphate insecticides have been in use for some time for tick and flea control, but again, the parasites appear to be developing resistance to organophosphates and their efficacy has dropped off considerably.
The present invention offers an alternative to the known systemic parasite control products. Tests have shown the instant invention to be nearly 100% effective in eliminating flea and tick infestation in cats and dogs. There have been no toxic effects on either dogs or cats tested. Hemograms and blood chemistries have remained normal in both dogs and cats.
SUMMARY OF THE INVENTION
The present invention is a method and composition for treating parasitic infestation in animals by the oral administration of a sufficient amount of a piperidine alkaloid composition to effectively control the parasitic infestation. Administration of Solenopsin A in oral dosage form or whole body extract of the imported red fire ant, Solenopsis invicta, over a period of days results in the elimination of ticks, fleas, and other mites without any toxic effects on the animals. This is particularly important in the systemic treatment of cats because of the toxicity of currently existing organophosphates to cats. It is anticipated that control of lice and other blood and tissue-fluid feeding parasites on and in humans may be achieved by the instant method and composition.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
Considerable research has been done on the imported red fire ant, Solenopsis invicta. Chemical studies on the venom of this insect have shown that the venon is 95% alkaloids and the remaining 5% contains solubilized proteins and amino acids. The alkaloid fractions are characterized by the presence of various 2, 6 di-substituted piperidines. The venom also contains enzymes including hyaluronidase and phospholipase.
Of the piperidine alkaloids, Solenopsin A and Solenopsin B are the two major components with Solenopsin A being the primary component. Solenopsin A is a trans-2-methyl-6-n-undecylpiperidine. Solenopsin B is 2, b-trans-dialkyl-piperidine. Solenopsin A and Solenopsin B may be produced synthetically by any number of known techniques.
In one embodiment of the present invention, live fire ants are captured and quickly frozen to preserve their freshness. Each ant contains approximately 40 nanoliters of venom. For the further purposes of this disclosure, each ant is considered to comprise approximately one unit of venom or 40 nanoliters of venom containing the alkaloids Solenopsin A and Solenopsin B.
After freezing, the ants are ground to a fine texture, inserted into soluble capsules as whole body extract along with and edible carrier material, and kept frozen until administred to the animals, as will be discussed further.
While pure venom may be utilized in the treatment of parasite infestation it may be more practical from a commercial standpoint to use whole body e
REFERENCES:
patent: 4910209 (1990-03-01), Rehmert
M. Bonin et al., Tet. Lefters, 23(33):3369-3372, 1882.
D. Grierson et al., J. Org. Chem. 51(23):4487-4477, 1986.
W. Carnuthers et al., Chem. Abst. 106:3359, 1986.
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