Enchancers for the transdermal flux of nivadipine

Details Enchancers for the transdermal flux of nivadipine Enchancers for the transdermal flux of nivadipine

1987-06-12

1991-03-19

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514946, 514947, 424449, A61K 3100, A61K 3144, A61F 1300

Patent

active

050011391

ABSTRACT:
The transdermal flux rates of 1,4-dihydropyridine derivatives, such as nilvapidine and its enantiomers may be increased by the use of a solvent vehicle which comprises dioctyl adipate, isopropyl myristate, benzyl alcohol, diisopropyl adipate, a mixture of 5 to 50% ethyl alcohol and 95-50% of diisopropyl adipate, or a mixture of any of the foregoing.

REFERENCES:
patent: 4284634 (1981-08-01), Satu
patent: 4338322 (1982-07-01), Satu
patent: 4537898 (1985-08-01), Hoff et al.
patent: 4685911 (1987-08-01), Konno et al.
Patent Abstracts of JP-vol. 10, No. 166 (C-353) (2222), 13th Jun. 1986; and JP-A- 61 18717 (Nichiban).

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