Pyridine derivatives

Details Pyridine derivatives Pyridine derivatives

Filed on

1989-06-16

Date issued

1991-03-19

Examiner

Page, Thurman K.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

514290, 514297, 514311, 514312, 514313, A61K 3144, A61K 3147

Type

Patent

Status

active

Patent number

050011316

Description

ABSTRACT:
The invention provides a method of relieving inflammation in a mammal inflicted with an imflammatory disease which method comprises treating said mammal with a therapeutically effective amount of a compound of formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, loweralkyl, cycloloweralkyl, loweralkoxy, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl, loweralkoxycarbonyl, aryl or aralkyl or 7-12 carbon atoms, or R.sup.1 and R.sup.2 taken together, or R.sup.2 and R.sup.3 taken together form a5,6, or 7 membered ring with the carbon atoms to which they are attached, which ring may be saturated or unsaturated and unsubstituted or substituted by loweralkyl or loweralkoxy, R.sup.4 represents hydrogen, loweralkyl, loweralkoxy, aryl or aralkyl of 7-12 carbon atoms, n is 1,2 or 3, m is 1,2 or 3, Ar represents phenyl which may be substituted by halogen, loweralkyl, loweralkoxy, haloloweralkyl, haloloweralkoxy, nitro, amino; cyano, loweralkylamino, diloweralkylamino, carboxy, loweralkoxycarbonyl, loweralkanoyl, loweralkanoylamino, aryl or aminoloweralkyl, X is NHSO.sub.2, NH, NHCO--, CH(OH), O, CO, S, SO or SO.sub.2, or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4576949 (1986-03-01), Smith

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