Catheter system for controllably releasing a therapeutic agent a

Details Catheter system for controllably releasing a therapeutic agent a Catheter system for controllably releasing a therapeutic agent a

1994-03-16

1995-11-28

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

604265, 6048901, 604 28, 128634, A61M 100

Patent

active

054703077

ABSTRACT:
A catheter having a therapeutic agent chemically bonded to a substrate on its exterior surface using a linker which photolytically releases the agent upon exposure to light energy at an appropriate wavelength. The linker is attached to the substrate via a complementary chemical group, with the opposing end containing an aromatic ring with a nitro group in the ortho position relative to a methyl or ethyl group which is functionalized to accept a complementary bond to the therapeutic agent. The substrate may include materials such as glass, polyamide, polyester, polyolefin, polypropylene, polyurethane, or latex. The therapeutic agent may include peptides, proteins, steroids, carbohydrates, nucleotides, or other aliphatic or heterocyclic products, and may be bonded to a molecular lattice or meshwork to accommodate a high molecular concentration per unit area and the inclusion of ancillary compounds such as markers or secondary emitters.

REFERENCES:
patent: 2883986 (1959-04-01), De Luca et al.
patent: 3435826 (1969-04-01), Fogarty
patent: 3467101 (1969-09-01), Fogarty et al.
patent: 3570476 (1971-03-01), Gregg
patent: 3901829 (1975-08-01), Slingluff et al.
patent: 4062746 (1977-12-01), Rich et al.
patent: 4156066 (1979-05-01), Gould
patent: 4156067 (1979-05-01), Gould
patent: 4195637 (1980-04-01), Gruntzig et al.
patent: 4271839 (1981-06-01), Fogarty et al.
patent: 4289128 (1981-09-01), Rusch
patent: 4323071 (1982-04-01), Simpson et al.
patent: 4359453 (1982-11-01), Gordon
patent: 4479497 (1984-10-01), Fogarty et al.
patent: 4531943 (1985-07-01), Van Tassel et al.
patent: 4545390 (1985-10-01), Leary
patent: 4554929 (1985-11-01), Samson et al.
patent: 4571240 (1986-02-01), Samson et al.
patent: 4573966 (1986-03-01), Weikl et al.
patent: 4581017 (1986-04-01), Sahota
patent: 4582181 (1986-04-01), Samson
patent: 4597755 (1986-07-01), Samson et al.
patent: 4610241 (1986-09-01), Gordon
patent: 4616648 (1986-10-01), Simpson
patent: 4702252 (1987-10-01), Brooks et al.
patent: 4743673 (1988-05-01), Johnston et al.
patent: 4748982 (1988-06-01), Horzewski et al.
patent: 4762129 (1988-08-01), Bonzel
patent: 4771130 (1988-09-01), Cohen
patent: 4799479 (1989-01-01), Spears
patent: 4807620 (1989-02-01), Strul et al.
patent: 4824436 (1989-04-01), Wolinsky
patent: 4835258 (1989-05-01), Hollenberg et al.
patent: 4846171 (1989-07-01), Kauphusman et al.
patent: 4878492 (1989-11-01), Sinofsky et al.
patent: 4895560 (1990-01-01), Papantonakos
patent: 4940055 (1990-07-01), Brown
patent: 4957481 (1990-09-01), Gatenby
patent: 4976690 (1990-12-01), Solar et al.
patent: 4994033 (1991-02-01), Shockey et al.
patent: 4997431 (1991-03-01), Isner et al.
patent: 5002531 (1991-03-01), Bonzel
patent: 5009659 (1991-04-01), Hamlin et al.
patent: 5026367 (1991-06-01), Leckrone et al.
patent: 5032666 (1991-07-01), Hu et al.
patent: 5047025 (1991-09-01), Taylor et al.
patent: 5053033 (1991-10-01), Clarke
patent: 5057106 (1991-10-01), Kasevich et al.
patent: 5061273 (1991-10-01), Yock
patent: 5086068 (1992-02-01), Raleigh et al.
patent: 5087256 (1992-02-01), Taylor et al.
patent: 5092841 (1992-03-01), Spears
patent: 5100429 (1992-03-01), Sinofsky et al.
patent: 5102402 (1992-04-01), Dror et al.
patent: 5106386 (1992-04-01), Isner et al.
patent: 5109859 (1992-05-01), Jenkins
patent: 5120322 (1992-06-01), Davis et al.
patent: 5126140 (1992-06-01), Ito et al.
patent: 5156594 (1992-10-01), Keith
patent: 5163898 (1992-11-01), Morcos et al.
patent: 5171217 (1992-12-01), March et al.
patent: 5171264 (1992-12-01), Merrill
patent: 5199951 (1993-04-01), Spears
patent: 5207670 (1993-05-01), Sinofsky
patent: 5217482 (1993-06-01), Keith
patent: 5232446 (1993-08-01), Arney
patent: 5236410 (1993-08-01), Granov et al.
patent: 5263992 (1993-11-01), Guire
E. Atherton & R. C. Sheppard; Solid Phase Peptide Synthesis a Practical Approach; Published by IRL Press 1989.
Donald A. Tomalia; Starburst.TM./Cascase Dendrimers: Fundamental Building Blocks for a New Nanoscopic Chemistry Set; Aldrichimica Acta, vol. 26, No. 4, 1993.
Kurt Nilsson and Klaus Mosbach; Tresyl Chloride-Activated Supports for Enzyme Immobilization; Methods in Enzymology, vol. 135 1987.
Stephen R. Adams and Roger Y. Tsien; Controlling Cell Chemistry With Caged Compounds; Am. Rev. Physiol. 1993.
James A. McCray and David R. Trentham; Properties and Uses of Photoreactive Caged Compounds; Am. Rev. Biophys. Chem. 1989.
Gordon W. McLean; Ania M. Owsianka; John H. Subak-Sharpe and Howard S. Marsden; Generation of Anti-Peptide and Anti-Protein Sera Effect of Peptide Presentation on Immunogenicity; Journal of Immunological Methods, 137 (1991).
E. Molnar, A.a Baude, S. A. Richmond, P. B. Patel, P. Somogyi, R. A. J. McIlhinney; Biocyhemical and Immunocytochemical Characterization of Antipeptide Antibodies to a Cloned GiuRl Glutamate Receptor Subunit: Cellular and Subcellular Distribution in the Rat Forebrain; Neuroscience, vol. 53, No. 2, pp. 307-326, 1993.
Communication to the Editor; Photosensitive Protecting Groups; Journal of the American Chemical Society, 92:21, Oct. 21, 1970.
V. N. Rajasekharan PILLAI; Photoremnovable Protecting Groups in Organic Synthesis; 1980 George Thieme Publishers.
M. S. Sheu; A. S. Hoffman; J. Feijen; A Glow Discharge Treatment to Immobilize Poly(ethytlene oxide)/Poly(propylene oxide) surfactants for Wettable and Non-Fouling Biomaterials; J. Adhesion Sci. Technol., vol. 6, No. 9, pp. 905-1009 (1992).
David N. Posnett; Helen McGrath; James P. Tam; A Novel Method for Producing Anti-Peptide Antibodies; The Journal of Biological Chemistry; Feb. 5, 1988.
Victor S. Goldmacher; Peter D. Senter, John M. Lambert; Walter A. Blattler; Photoactivation of Toxin Conjugates; Bioconjugate Chem., vol. 3, No. 2, 1992.
R. B. Merrifield; Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide; Jul. 20, 1963.
Obed W. Odom; Hung-Yin Deng; Alap R. Subramanian; Boyd Hardesty; Relaxation Time Interthiol Distance, and Mechanism of Action of Ribosomal Protein S1; Archives of Biochemistry and Biophysics; vol. 230, No. 1, pp. 178-193, Apr., 1984.
James P. Tam; Synthetic Peptide Vaccine Design; Synthesis and Properties of a High-Density Multiple Antigenic Peptide System; Proc. Natl. Acad. Sci. USA, vol. 85, pp. 5409-5413, Aug., 1988.
Protein Modification, Section E: ImmunoTechnology Catalog & Handbook; Published by Pierce.
H. Yasuda; Plasma Polymerization; Academic Press, 1985.
R. S. Schwartz, J. G. Murphy; W. D. Edwards; D. R. Holmes; Bioabsorbable, Drug-Eluting, Intracoronary Stents: Design and Future Applications; Coronary Stents, pp. 135-153, 1992.
D. J. Inman; W. E. Hornby; The Immobilization of Enzymes on Nylon Structures and Their Use in Automated Analysis; Biochem. J. 129, pp. 255-262, 1972.
N. J. Daka; K. J. Laidler; Flow Kinetics of Lactate Dehydrogenase Chemically Attached to Nylon Tubing; Can J. Biochem. vol. 56, 1978.
Communications to the Editor; Chemically Modified Polyesters as Supports for Enzyme Immobilization: Isocyanide, Acylhydrazide, and Aminoaryl Derivatives of Poly(ethylene Terephthalate); Biotechnology and Bioengineering, vol. XX, pp. 309-315 (1978).
T. T. Ngo; K. J. Laidler; C. F. Yam; Kinetics of Acetylcholinesterase Immobilized on Polyethylene Tubing; Can. J. Biochem., vol. 57, 1979.
Peter D. Senter; Marilyn J. Tansey; John M. Lambert; Walter A. Blaittler; Novel Photocleavable Protein Crosslinking Reagents and Their Use in the Preparation of Antibody-Toxin Conjugates; Photochemistry and Photobiology, vol. 42, No. 3, pp. 231-237, 1985.
Jeffery W. Walker; Gordon P. Reid; James A. McCray; David R. Trentham; Photolabile 1-(2 Nitrophenyl)ethyl Phosphate Esters of Adenine Nucleotide Analogues. Synthesis and Mechanism of Photolysis; J. Am Chem. Soc., vol. 110, No. 21, pp. 7170-7177 (1988).
Daniel H. Rich; S. K. Gurwara; Preparation of a New o-Nitrobenzyl Resin for Solid-Phase Synthesis of tert-Butyloxycarbonyl-Protected Peptide Acids; Journal of the American Chemical Society; 97:6; Mar. 19, 1975.
Ole Buchardt; Ulla Henriksen; Troels Koch; Peter E. Nielsen; Photolabeling Reagent Design; P. E. Nielsen (ed.), Photochemical Probes in Biochemistry, 1-9, 1989.

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