Microencapsulation and electrostatic processing method

Details Microencapsulation and electrostatic processing method Microencapsulation and electrostatic processing method

1998-05-15

2000-08-15

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424450, 424489, 424491, 424497, 424498, 4272133, 42840221, 42840224, 5147723, 514773, 264 432, 264 433, A61K 950

Patent

active

061032719

ABSTRACT:
Methods are provided for forming spherical multilamellar microcapsules having alternating hydrophilic and hydrophobic liquid layers, surrounded by flexible, semi-permeable hydrophobic or hydrophilic outer membranes which can be tailored specifically to control the diffusion rate. The methods of the invention rely on low shear mixing and liquid-liquid diffusion process and are particularly well suited for forming microcapsules containing both hydrophilic and hydrophobic drugs. These methods can be carried out in the absence of gravity and do not rely on density-driven phase separation, mechanical mixing or solvent evaporation phases. The methods include the process of forming, washing and filtering microcapsules. In addition, the methods contemplate coating microcapsules with ancillary coatings using an electrostatic field and free fluid electrophoresis of the microcapsules. The microcapsules produced by such methods are particularly useful in the delivery of pharmaceutical compositions.

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patent: 5545423 (1996-08-01), Soon-Shiong et al.

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