Compounds and methods for changing calcium metabolism within the

Details Compounds and methods for changing calcium metabolism within the Compounds and methods for changing calcium metabolism within the

1981-05-06

1983-07-12

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424282, C07D31744, A61K 3136

Patent

active

043932266

ABSTRACT:
2-alkyl-5,6-dialkoxy (or 5,6 alkylenedioxy) indenes and indane-1-di- or trialkylammonium salts are useful as calcium antagonists, for example in arrhythmia. The compounds are prepared from the known corresponding 2,5,6-substituted indene-1-dimethylammonium salts by alkylation and/or hydrogenation.

REFERENCES:
patent: 2541967 (1951-02-01), Kolloff et al.
patent: 2916490 (1959-12-01), Schenck et al.
patent: 3201470 (1965-08-01), Huebner
patent: 3253037 (1966-05-01), Huebner
D. T. Witiak, D. R. Williams, S. V. Kakodkar, C. Hite and M. S. Chen, J. Org. Chem., 39, 1242 (1974).
R. G. Rahwan, M. M. Faust and D. T. Witiak, J. Pharmacol. Exp. Ther., 201, 126 (1977).
M. F. Piascik, R. G. Rahwan and D. T. Witiak, J. Pharmacol. Exp. Ther., 205, 155 (1978).
D. T. Witiak, S. V. Kakodkar, T. P. Johnson, J. R. Baldwin and R. G. Rahwan, J. Med. Chem., 22, 77 (1979).
C. E. Akesson, R. G. Rahwan, D. T. Witiak, R. J. Brumbaugh, Res. Commun. Chem. Pathol., Pharmacol., 27, 265, (1980).
R. G. Rahwan, M. F. Piascik, D. T. Witiak, Canad. J. Physiol. Pharmacol., 57, 443, (1979).
M. F. Piascik, R. G. Rahwan and D. T. Witiak, J. Pharmacol. Exp. Ther., 210, 141 (1979).
M. F. Piascik, M. T. Piascik, D. T. Witiak and R. G. Rahwan, Canad. J. Physiol. Pharmacol., 57, 1350 (1979).
R. G. Rahwan, C. E. Akesson and D. T. Witiak, Res. Common. Chem. Pathol. Pharmacol., 26, 85 (1979).
J. L. Lynch, R. G. Rahwan, and D. T. Witiak, J. Card. Pharmcol., 60, 49 (1981).

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