Oligonucleotides with modified phosphate and modified carbohydra

Details Oligonucleotides with modified phosphate and modified carbohydra Oligonucleotides with modified phosphate and modified carbohydra

1985-07-18

1991-01-01

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 2102

Patent

active

049819577

ABSTRACT:
The invention relates to novel oligonucleotides, the process for their preparation and their biological uses as mediators of the action of interferon. The oligonucleotides according to the invention have the formula: ##STR1## in which Y and T are identical or different and represent particularly O, S, Z and W are identical or different and represent particularly O, S, one at least of the elements Y and Z being different from oxygen, X represents particularly --CHOHCH.sub.2 OH, .SIGMA. is a whole number equal to or greater than 2, A represents adenine or one of its derivatives. These oligonucleotides have antiviral use.

REFERENCES:
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Hughes et al, Biochemistry, vol. 22, No. 9, pp. 2127-2135 (1983).
Kariko et al, Chem. Abstr., 103, 16829h, 1985.
Knight et al., Methods in Enzymology, vol. 79, pt. A., pp. 216-227, 1981.
Eppstein et al., Nature, vol. 302, pp. 723-724, 1983.
Justesen et al., Proc. Nat. Acad Sci (Biochem)., vol. 77, pp. 4618-4622, 1980.
March, Advanced Organic Chemistry, McGraw-Hill Book Co., 1968, New York, pp. 306 (Acetal Hydrolysis) & 678 (BH.sub.4.sup..crclbar. +Aldehydes).

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