Nitrogen containing heterocyclic compounds, their production and

Details Nitrogen containing heterocyclic compounds, their production and Nitrogen containing heterocyclic compounds, their production and

1991-03-07

1994-04-19

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514259, 514260, 514269, 514312, 514345, 514350, 514351, 544284, 544287, 544326, 544328, 544329, 546153, 546276, 546298, 546300, 546301, 546302, A61K 3144, A61K 31505, C07D21363, C07D23990

Patent

active

053045653

ABSTRACT:
Nitrogen-containing heterocyclic compounds of the formula (I): ##STR1## wherein Y is N or CH; R.sup.1, which may be optionally bound through a hetero atom, is a hydrocarbon residue which may be substituted; R.sup.2 and R.sup.3 which may be same or different, are each independently hydrogen, cyano, nitro, optionally substituted lower alkyl, or --COD wherein D is alkoxy, hydroxy, halogen, or optionally substituted amino: or R.sup.2 and R.sup.3 are taken together to form a benzene ring which may be substituted; the dotted line is a chemical bond; Z is bound to a hetero nitrogen atom and is a group having the formula: ##STR2## wherein R.sup.4 is hydrogen, halogen or nitro, and R.sup.5 is a residue capable of forming an anion or a residue convertible into an anion; A is a direct bond or a spacer having atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonist activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, etc.

REFERENCES:
patent: 4668682 (1987-05-01), Sekiya et al.
patent: 4880804 (1989-11-01), Carini et al.
patent: 5100897 (1992-03-01), Allen et al.
patent: 5166206 (1992-11-01), Allen et al.
patent: 5240928 (1993-08-01), Allen et al.
Chiu et al., European Journal of Pharmacology 157:13-21 (1988).

Affiliated with

Also associated with

Rating

Nitrogen containing heterocyclic compounds, their production and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nitrogen containing heterocyclic compounds, their production and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitrogen containing heterocyclic compounds, their production and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-19954