Method for the preparation of .beta.-thiolactam compound

Details Method for the preparation of .beta.-thiolactam compound Method for the preparation of .beta.-thiolactam compound

1996-03-08

1996-12-17

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D205095

Patent

active

055854877

ABSTRACT:
Disclosed is a method for the preparation of a .beta.-thiolactam compound, i.e. a 7-substituted-2-oxa-7-azabicyclo [3.2.0]-heptan-6-thione, represented by the general formula ##STR1## in which R is an alkyl or aryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isothiocyanate compound R--NCS, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher at an elevated temperature.

REFERENCES:
Chemisch Berichte, vol. 115, p. 3340 (1982) (with Chem. Abstr., vol. 98, 98:16849c).
Chem. Abstr., vol. 65, 3818c (1966).

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