Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-10-04
1996-12-17
Low, Christopher S. F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530359, 536 231, 536 235, 930 10, C07K 1447
Patent
active
055854621
ABSTRACT:
The present invention provides isolated nucleic acid sequences, i.e., polynucleotides, which encode a family of perilipin proteins. The present invention also provides isolated, substantially purified perilipin proteins which are useful as markers for differentiating true adipocytes from non-adipocyte cells which, as a result of pathophysiological conditions, assume adipocyte characteristics and become lipid-laden. The present invention further provides methods for producing a substantially purified perilipin protein and methods for detecting the presence of such perilipin proteins in a biological samples.
REFERENCES:
patent: 4675285 (1987-06-01), Clark et al.
Webster's II New Riverside Univesity Dictonary, 1984, Houghton-Mifflin Co., Boston, MA, p. 67.
A. S. Greenberg et al., "Biochemistry of A Major, Hormonally-Regulated, Phosphoprotein Associated With the Lipid Storage Droplet in Adipocytes," (Am. Soc. biochem. Mol. Biol.) Joint Meeting 4-7 Jun 1990 abstract 3108,
A. S. Greenberg et al., "Perilipin, A Lipid Droplet-Associated, Adipocyte Specific Protein; cDNA Cloning and Expression," 1991 Meeting (May 1991)--Abstract.
A. S. Greenberg et al., "Biochemistry and Hormonal Regulation of The Major Phosphoprotein Associated With The Lipid Storage Droplet In Adipocytes," Mid-Atlantic Lipid Clubs, Apr. 25-27, 1990--Abstract.
J. J. Egan et al., "Control of Endogenous Phosphorylation of the Major cAMP-dependent Protein Kinase Substrate In Adipocytes by Insulin and .beta.-Adrenergic Stimulation," The J. of Biol. Chem., vol. 265, 31, pp. 18769-18775, Nov. 5, 1990.
W. B. Benjamin et al., "Actions of Insulin, Epinephrine, and Dibutyryl Cyclic Adenosine 5'-Monophosphate on Fat Cell Protein Phosphorylations, Cyclic Adenosine 5'-Monophosphate Dependent and Independent Mechanisms," Biochemistry, vol. 4, 15, pp. 3301-3309, 1975.
W. B. Benjamin et al., "Action of Insulin and Catecholamines on the Phosphorylation of Proteins Associated with the Cytosol. membranes, and Fat Cake" of Rat Fat Cells, The J. of Biol. Chem., vol. 253:1700, Mar. 10, 1978,
Alan R. Kimmel et al., "cDNA Cloning and Expression of Perilipin, A Lipid Droplet-Associated, Adipocyte-Specific Protein," CA 309, J. of Cell. Biochem., Suppl. 15B, Jan. 18-25, 1991--Abstract, p. 31.
A. S. Greenberg et al., "Perilipin, A Major, Hormonally-Regulated, Adipocyte-Specific Phosphoprotein Associated With The Periphery of Lipid Storage Droplets," CA 306, J. of Cell. Biochem., Suppl. 15B, Jan. 18-25, 1991--Abstract, p. 30.
Constantine Londos et al., "Control of Isolated Adipocytes, Enzyme Trafficking, and The Surface of The Lipid Storage Droplet," CA 012, J. of Cell. Biochem., Suppl. 15B, Jan. 18-25, 1991--Abstract, p. 7.
Egan John J.
Greenberg Andrew S.
Kimmel Alan R.
Londos Constantine
Low Christopher S. F.
United States of America
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