Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 24 amino acid residues in defined sequence
Patent
1994-03-24
1996-12-17
Cunningham, Thomas M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
24 amino acid residues in defined sequence
530300, 530395, 530868, 4241851, C07K 706, A61K 3808
Patent
active
055854613
ABSTRACT:
Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
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Bastin Judy
Boon-Falleur Thierry
Coulie Pierre
Townsend Alan
van der Bruggen Pierre
Cunningham Thomas M.
Ludwig Institute for Cancer Research
The Chancellor, Masters and Scholars of the University of Oxford
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