Heterocyclic compounds, their production and use as tachykinin r

Details Heterocyclic compounds, their production and use as tachykinin r Heterocyclic compounds, their production and use as tachykinin r

1994-11-10

1996-12-17

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

574299, 574301, 574302, 546114, 546115, 546122, 546123, 546153, 546156, 546167, 546168, A61C 3144, A61C 3147, A61C 31435, C07D47104

Patent

active

055853854

ABSTRACT:
A novel compound represented by the formula: ##STR1## wherein Ring A and Ring B respectively stands for an optionally substituted homo- or hetero-cyclic ring, and at least one of them stands for an optionally substituted heterocyclic ring stand; Ring C stands for an optionally substituted benzene ring; R stands for a hydrogen atom or an optionally substituted hydrocarbon residue; one of X and Y stands for --NR.sup.1 -- (R.sup.1 stands for a hydrogen atom or an optionally substituted hydrocarbon residue) or --O--, and the other stands for--CO-- or --CS--, or one of them stands for --N.dbd. and the other stands for .dbd.CR.sup.2 -- (R.sup.2 stands for a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon residue, an optionally substituted amino group or an optionally substituted hydroxyl group); n denotes 1 or 2 or salts thereof which have an excellent tachykinin receptor antagonistic action and inhibitory action on plasma extravasation.

REFERENCES:
patent: 5143919 (1992-09-01), Meguro
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"Action of Grignard Reagents and of Ketones on 3-Phenyl Carbamoyl . . . ", M. El-Kady, et al., Egypt J. Chem., vol. 28, No. 1, . 63-70 (1985).
"Some Reactions on 3N-Aryl-Carbamido Coumarines and 4-Methyl-5,6-Benzocoumarin", M. El-Mobayed, et al., Anales de Quimica, vol. 86, pp. 59-61 (1990).
"Synthese und antikonvulsive Aktivit at von 3-Carbamoyl-4-aryl-isochinolin-1(2H)onen", Klaus Unverferth, et al., Arch. Pharm., vol. 324, 809-814 (1991).

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