Method of ophthalmic drug delivery

Details Method of ophthalmic drug delivery Method of ophthalmic drug delivery

1992-12-19

1994-11-22

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Phosphorus or phosphorus compound

424682, 424686, 424687, 424696, A61K 3342, A61K 3306, A61K 3310

Patent

active

053667395

ABSTRACT:
A method for prolonged delivery of a therapeutic agent to the eye is disclosed. The method provides for the addition of a desired drug to a suitable, preferably non-aqueous, vehicle. An amount of the vehicle containing a therapeutic dose of the drug is placed on the extraocular skin adjacent to the lateral canthus of the eye. Movements of the orbicularis oculi associated with the scissor-like closing of the lids of the eye continuously transport small portions of the drug containing vehicle into the interpalpebral space where the drug is released to the cornea for intraocular penetration and treatment effected. The method of the invention is particularly effective in delivering insoluble calcium salts for the treatment of dry eye.

REFERENCES:
Physician's Desk Reference for Ophthamology, 16 Edition, 1988, pp. 13, 153 and 154.
Physician's Desk Reference for Ophthamology, 16 Edition, 1988. pp. 9, 11 and 12.
PTS Newsletter Database. Bausch & Lomb Dry eye Therapy lubricating Eye drops.

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