Polymeric active methylene compounds

Details Polymeric active methylene compounds Polymeric active methylene compounds

1984-02-17

1984-12-18

Schofer, Joseph L.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525374, 525383, 526287, 526316, C08F 830

Patent

active

044891970

ABSTRACT:
Polymeric compounds which have recurring ##STR1## units, wherein X is N or O, R.sub.1, R.sub.2 and R.sub.3 are hydrogens or lower alkyls and R.sub.4 is ##STR2## and aromatic amine or an aromatic hydrazine which provides X as N. These polymers provide active methylene groups which serve as points of attachment for organic groups-particularly azo functionality-containing groups. These azo links can be cleaved by bacteria in the mammalian lower bowel, thereby releasing the corresponding amino groups. This mechanism can effect programmed delivery of pharmaceutically desirable species to the lower bowel.

REFERENCES:
patent: 3607834 (1971-09-01), Marx et al.
patent: 4011201 (1977-03-01), Ponticello
patent: 4296226 (1981-10-01), Braun et al.
C.A. vol. 84, 1976, 84: 1808408, Panarin, et al.
C.A. vol. 83, 1975, 95445, Krause et al.
C.A. vol. 80, 1974, 48525d, Plate et al.

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