Surgery – Means for introducing or removing material from body for... – Gas application
Patent
1995-02-03
1996-12-17
Green, Randall L.
Surgery
Means for introducing or removing material from body for...
Gas application
604 28, 604 52, A61M 2100
Patent
active
055848044
ABSTRACT:
The invention discloses methods for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patient's condition. The methods include the steps of instrumentizing (e.g., catheterizing, cannulating, injecting, etc.) the vessels or tissues around the organ, or the organ itself sought to be preserved and/or resuscitated, the body cavity, or cavities of the body, and introducing a temperature-controlled solution to preserve and/or resuscitate the organ(s). The temperature-controlled organ preservation solution includes components such as oxygen carrying agents, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents. A device which performs this method is also disclosed. This device includes a fluid reservoir, an oxygen tank, a heat exchanger and removable catheter lines.
REFERENCES:
patent: 1682344 (1928-08-01), Lesieur
patent: 1916658 (1933-07-01), Davidson
patent: 3091242 (1963-05-01), Johnson et al.
patent: 3406531 (1968-10-01), Swenson et al.
patent: 3632473 (1972-01-01), Belzer et al.
patent: 4378797 (1983-04-01), Osterholm
patent: 4393863 (1983-07-01), Osterholm
patent: 4445500 (1984-05-01), Osterholm
patent: 4451251 (1984-05-01), Osterholm
patent: 4657532 (1987-04-01), Osterholm
patent: 5085630 (1992-02-01), Osterholm et al.
patent: 5145771 (1992-09-01), Lemasters et al.
patent: 5149321 (1992-09-01), Klatz et al.
patent: 5200176 (1993-04-01), Wong et al.
patent: 5217860 (1993-06-01), Fahy et al.
patent: 5234405 (1993-09-01), Klatz et al.
patent: 5395314 (1995-03-01), Klatz et al.
"Cerebral Blood Flow, Vasoreactivity, and Oxygen Consumption During Barbiturate Therapy in Severe Traumatic Brain Lesions", by Carl-Henrick Nordstrom, MD et al., J. Neurosurg, vol. 68, Mar. 1988, pp. 424-431.
"At Surgery's Frontier: Suspended Animation", by Elisabeth Rosenthal, The New York Times, Nov. 13, 1990, pp. C1, C12.
"Randomized Clinical Study of Thiopental Loading in Comatose Survivors of Cardiac Arrest", The New England Journal of Medicine, vol. 314, No. 7, Feb. 13, 1986, pp. 397-403.
"Current Concepts in Brain Resuscitation", By Mark C. Rogers, MD, Journal of the American Medical Association, vol. 261, No. 21, pp. 3143-3147.
"Cerebrovascular Hypoxic and Autoregulatory Responses During Reduced Brain Metabolism", by Judith H. Donegan et al., The American Physiological Society, (1985), vol. 249, pp. H421-H429.
"Regional Cerebral Blood Flow In Normal Blood Circulated and Perfluorocarbon Transfused Rats", Advances in Experimental Medicine and Biology, (1986), vol. 200, pp. 59-65.
"Protection from Cerebral Air Emboli with Perfluorocarbons in Rabbits", Bruce D. Spiess, MD, et al., Stroke, vol. 17, No. 6, Nov.-Dec. 1986, pp. 1146-1149.
"Free Radicals and Myocardial Ischemia and Reperfusion Injury", by Paul J. Simpson, J. Lab. Clin. Med., Jul. 1987, pp. 13-30.
"Increases in Brain Tumor and Cerebral Blood Flow by Blood-Perfluorochemical Emulsion (Fluosol-DA) Exchange", by Shoju Hiraga et al., Cancer Research, vol. 47, No. 12, pp. 3296-3302.
"Polarographic Cerebral Oxygen Availability, Fluorocarbon Blood Levels and Efficacy of Oxygen Transport by Emulsions", by Leland C. Clark, Jr. et al., Biomaterials, 16(1-3), (1988), pp. 375-393.
"The Nature of Fluorocarbon Enhanced Cerebralk Oxygen Transport", by Leland C. Clark, Jr. et al., Advances in Experimental Medicine and Biology, vol. 248, pp. 341-355.
"Easier Breathing in RDS", Medical Tribune, Jan. 11, 1990, p.2.
"Cerebral Ischemic Injury", by Blaine C. White, Emergency Medicine A Comprehensive Study Guide, 1988 pp. 9-10.
"90s Could See Brain Injury Reversal", American Medical News, Nov. 17, 1989, p. 66.
"Cooling Brain May Limit Stroke Damage", American Medical News, Nov. 17, 1989, p. 66.
"Drug May Preserve Heart Tissue After Attack", New York Times, Sep. 5, 1989, p. 3.
"Radical Therapy", By Karen Wrig, Scientific American, Sep. 1987.
"Diseases of the Central Nervous System", Asbury, McKhann, McDonald, pp. 1071 and 1083.
"Resuscitation of the Rabbit Brain After Acute complete Ischemia Lasting Up To One Hour: Pathophysiological and Pathomorphological Observations", by Ryszard Pluta, Resuscitation 15, (1987), pp. 267-287.
"The Use of Blood Substitutes for Whole Body Perfusion in Ultra-Profound Hypothermic Cardiac Arrest", Amr M. Elrifai et al., Annals of Clin. and Lab. Science, vol. 20, No. 4, Jul.-Aug. 1990, p. 292.
"Nutritional Aspects of Ambulatory Care", American Family Physicians, vol. 42, No. 3, Sep. 1990, pp. 557-558.
"In Situ Cadaver Kidney Perfusion", by Robert T. Schweizer et al., Transplantation, Official Journal of the Transplantation Society, vol. 32, No. 6, Dec. 1981, pp. 482-484.
"In situ kidney preservation for transplantation with use of profound hypothermia (5 to 20.degree. C.) with an intact circulation", by A. R. Moossa et al., Surgery, vol. 79, No. 1, Jan. 1976, pp. 60-64.
"Extracorporeal perfusion for obtaining postmortem homografts", by T. L. Marchioro, M.D. et al., Surgery, vol., 54, No. 6, Jul.-Dec., 1963, pp. 900-911.
"Use of Extracorporeal Cadaver Perfusion for Preparation of Organ Homografts", by T. L. Marchioro, M.D., Surgical Forum, vol. XIV, Oct., 1963, pp. 174-176.
"Donor Core-Cooling Provides Improved Static Preservation for Heart-Lung Transplantation", by Charles D. Fraser, Jr., M.D., The Annals of Thoracic Surgery, vol. 45, No. 3, Mar. 1988, pp. 253-257.
Goldman Robert M.
Klatz Ronald M.
Green Randall L.
Life Resuscitation Technologies, Inc.
Smith Chalin
LandOfFree
Brain resuscitation and organ preservation device and method for does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Brain resuscitation and organ preservation device and method for, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Brain resuscitation and organ preservation device and method for will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1987702