Renin inhibitors containing phenylalanyl-histidine replacements

Details Renin inhibitors containing phenylalanyl-histidine replacements Renin inhibitors containing phenylalanyl-histidine replacements

1989-03-08

1991-08-06

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514211, 514212, 5142222, 5142358, 5142372, 514365, 514396, 514613, 514616, 514618, 514706, 514707, 514708, 514709, 514712, 530330, 530331, 544 582, 544 584, 544131, 544139, 544159, 548331, 558 25, 560 12, 564154, 564162, A61K 3116, A61K 3118, A61K 3702, A61K 3141, A61K 31505, C07K 506, C07D27910

Patent

active

050378074

ABSTRACT:
Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.

REFERENCES:
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Denkewalter et al., Progress in Drug Research, vol. 10, 1966, pp. 610-612.
Plattner et al., J. Med. Chem., 1988, 31(12), pp. 2277-2288.

Affiliated with

Also associated with

Rating

Renin inhibitors containing phenylalanyl-histidine replacements does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Renin inhibitors containing phenylalanyl-histidine replacements, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Renin inhibitors containing phenylalanyl-histidine replacements will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1987056