2-Amino-4-pyrimidyl-1,4-dihydropyridine derivatives

Details 2-Amino-4-pyrimidyl-1,4-dihydropyridine derivatives 2-Amino-4-pyrimidyl-1,4-dihydropyridine derivatives

1975-05-07

1977-05-10

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602564C, 2602564R, 260283CN, 260287K, 260283S, 4288R, C07D23924

Patent

active

040228983

ABSTRACT:
2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further substituted by a carbonyl group in the 3-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and an amidine.

REFERENCES:
patent: 2359329 (1944-10-01), Phillips
patent: 3544577 (1970-12-01), Seeger
Klingsberg, "Heterocyclic Compounds", 1960, pp. 365-376.

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