Tripeptides and methods for their production

Details Tripeptides and methods for their production Tripeptides and methods for their production

1976-01-19

1977-05-10

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 424177, C07C10352

Patent

active

040227596

ABSTRACT:
New tripeptides having the formula A-R.sub.1 -Tyr(benzyl)-Ser(benzyl)-R.sub.2 wherein A is t-butoxycarbonyl or cyclohexylcarbonyl, R.sub.1 is Trp, His(benzyl), Cys(benzyl) or Pro and R.sub.2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino, methods for their production, and the use of said tripeptides as luteinizing hormone releasing factor antagonists.

REFERENCES:
patent: 3725380 (1973-04-01), Konig et al.
J. M. Stewart and J. D. Young, "Solid Phase Peptide Synthesis," Freeman and Co., San Francisco, 1969, pp. 9-13.
J. D. Roberts and M. C. Caserio, "Basic Principles of Organic Chemistry," Benjamin, Inc., New York, 1965, p. 564.
E. Schroder and K. Lubke, "The Peptides," vol. 1, Academic Press, New York, 1965, pp. 108-111.

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