Method of selectively inhibiting calcium-independent myocardial

Details Method of selectively inhibiting calcium-independent myocardial Method of selectively inhibiting calcium-independent myocardial

1990-10-02

1993-05-04

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514460, 514473, A61K 3144, A61K 3135, A61K 3134

Patent

active

052082440

ABSTRACT:
Inhibition of calcium-independent myocardial phospholipase A.sub.2 is shown for compounds of the formula: ##STR1## wherein R and R.sup.1 independently represent hydrogen and halogen, alkyl, alkenyl and alkynyl radicals; R.sup.2 represents aryl, aryloxy, and heteroaryl radicals; and X is 1 or 2.

REFERENCES:
patent: 4602006 (1986-07-01), Krantz et al.
Krafft, G. A. J. Am. Chem. Soc. 103(18):5459-5466 (1981) [CA 95(15) 132580].

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