Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-05-13
1993-05-04
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142305, 514291, 514294, 540455, 540456, 544105, A61K 3133, A61K 31535, A61K 3144, C07D49812
Patent
active
052082288
ABSTRACT:
Aminomacrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by incorporation of a nitrogen substituent at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses. Also, these macrolides are useful in the treatment of reversible obstructive airways disease, particularly asthma.
REFERENCES:
patent: 4650803 (1987-03-01), Stella et al.
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 4916138 (1990-04-01), Ueda et al.
patent: 4929611 (1990-05-01), Okuhara et al.
patent: 4956352 (1990-09-01), Okuhara et al.
patent: 4981792 (1991-01-01), Inamine et al.
patent: 4987139 (1991-01-01), Chen et al.
patent: 5064835 (1991-11-01), Bochis et al.
Tanaka, et al., J. Am. Chem. Soc., 1987, 109, 5031-5033.
Bierer, et al., Science, 1990, 250, 556-559.
Donald, et al., Tetrahedron Lett., 1991, 32, 1375-1378.
C. Arita, et al., Clin. Exp. Immunol, 1990, 82, 456-461.
N. Murase, et al., Diabetes, 1990, 39, 1584-1586.
J. McCauley, et al., Lancet, 1990, 335, 674.
K. Takabayashi, et al., Clin. Immunol. Immunopathol., 1989, 51, 110-117.
U.S. Ser. No. 486,700 Bochis, et al. Mar. 1, 1990.
U.S. Ser. No. 516,598 Goulet, et al. Apr. 30, 1990.
U.S. Ser. No. 551,811 Beattie, et al. Jun. 25, 1990.
U.S. Ser. No. 596,177 Bochis, et al. Oct. 11, 1990.
U.S. Ser. No. 598,440 Ok, et al. Oct. 22, 1990.
U.S. Ser. No. 687,366 Goulet Apr. 18, 1991.
U.S. Ser. No. 698,886 Goulet, et al. May 13, 1991.
U.S. Ser. No. 698,889 Sinclair, et al. May 13, 1991.
U.S. Ser. No. 699,407 Goulet, et al. May 13, 1991.
Beattie Thomas R.
Fisher Michael H.
Goulet Mark
Ok Hyun O.
Wyvratt Matthew J.
Caruso Charles M.
Merck & Co. , Inc.
Thies J. Eric
Tsang Cecilia
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