Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1999-08-06
2000-10-03
Padmanabhan, Sreeni
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
568433, 568814, C07C 4563
Patent
active
061275816
ABSTRACT:
Fluorinated benzaldehydes are obtainable in a simple and inexpensive manner and in significantly improved yields when chlorinated benzaldehydes are reacted with alkali metal fluorides at temperatures in the range from about 130 to 200.degree. C. in the presence of less than about 2 mol % of quaternary phosphonium salts, based on chlorine atoms to be replaced, at initial concentrations of more than 2.5 mol of the chlorinated benzaldehydes per kg of dipolar aprotic solvent. Fluorinated benzaldehydes obtained in this way can advantageously be hydrogenated with hydrogen in the presence of noble metal catalysts to give fluorinated benzyl alcohols.
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J. English et al: "The Synthesis of 3,5-difluoro- and 3-fluoro-5-iodo-dl-tyrosine", J. American Chem. Soc., Bd. 62, 1949, Seite 350-353 XP002124525.
Harrison et al, Compendium of Organic Synthetic Methods, pp. 80-84, 1971.
Dreisbach Claus
Marhold Albrecht
Wiedemann Jurgen
Bayer Aktiengesellschaft
Eyl Diderico van
Gil Joseph C.
Padmanabhan Sreeni
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