Cloning and identification of a two component signal transducing

Details Cloning and identification of a two component signal transducing Cloning and identification of a two component signal transducing

1995-06-05

1997-02-25

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435822, 530825, 930200, C07K 100, C07K 1400, C07K 1700, C12N 100

Patent

active

056060220

ABSTRACT:
This invention relates to a purified isolated DNA fragment of Bacteroides fragilis comprising a sequence for an operon containing two genes designated rprX and rprY. These genes encode two signal transducing regulatory proteins designated RprX and RprY. This invention further relates to the proteins RprX and RprY encoded by the operon. RprX and RprY affect the normal regulation of OmpF by OmpR and EnvZ.

REFERENCES:
patent: 4970147 (1990-11-01), Huala et al.
Dutta et al. (1996) J. Biol. Chem. 271(3):1424-1429.
Rasmussen et al. (1993) Mol. Microbiol. 7(5):765-776.

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