Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1993-02-12
1996-11-26
Fitzgerald, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530350, 530403, 435 691, 435 697, 424525, C07K 14715, A61K 3817
Patent
active
055787070
ABSTRACT:
Soluble human IFN-gamma receptor extracellular fragment and salts, functional derivatives, precursors and active fractions thereof are provided in substantially purified form. They are useful as pharmaceutically active substances for protecting against the deleterious effects of IFN-gamma, e.g. in autoimmune diseases.
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Bertini, Riccardo et al, "Urinary TNF-binding protein ( TNF soluble receptor) protects mice against the lethal effect of TNF nd endotoxic shock", Eur. Cytokine Netw., vol. 4, No. 1, pp. 39-42 (1993).
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Engelmann, Hartmut et al, "Two Tumor Necrosis Factor-binding Proteins Purified from Human Urine", J. of Biological Chemistry, vol. 265, No. 3, pp. 1531-1536 (1990).
Lesslauer, Werner et al, "Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality", Eur. J. Immunol., vol. 21, pp. 2883-2886, (1991).
Novick, D. et al, "Molecular Cloning and Characterization of a Fragment of the Human IFN-.gamma. Receptor", J. of Interferon Research, vol. 8, p. S58 (1988).
Aguet, et al.; Cell, 55:273-280 (1988); Molecular Cloning and Expression of the Human Interferon-- Reeptor.
Smith, D. H., et al. (1987) Science 238:1704-07.
Novick, et al. (Jun. 1990) J. Chromatography 510: 331-337.
Novick, et al. (Oct. 1989) J. Exp. Med. 170: 1409-1414.
Novick Daniela
Rubinstein Menachem
Cooper Iver P.
Fitzgerald David L.
Yeda Research and Development Co. Ltd.
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